Preheat the oven to 350 degrees. Line a muffin pan with cupcake liners and/or non-stick cooking spray.
In a stand mixer, or a large bowl combine the flour, sugar, baking soda, baking powder, pumpkin pie spice, and salt. Mix it up until combined well.
In a separate bowl combine the pumpkin puree, butter, vanilla extract, and the egg. Mix it well so that it is thoroughly combined.
Add the wet ingredients into the large ingredients and mix with the stand mixer, or a whisk until it combined and fully incorporated.
Using a scoop or a large spoon, fill the cupcake liners until they are about ¾ full.